Cannabis Ingredient May Prevent Mad Cow Disease

My explanation about the cannabidiol and mad cow disease prevention

1. Cannabinoids are antagonists of the NMDA receptors- so neurodegenerative diseases treatment

Excessive activation of glutamate receptors, particularly of the N-methyl-D-aspartate (NMDA) receptor subtype, leads to neuronal degeneration and death.
Since NMDA receptors are one of the most harmful factors in excitotoxicity, antagonists of the receptors have held much promise for the treatment of conditions that involve excitotoxicity, including neurodegenerative diseases. Cannabinoids are known to inhibit calcium channels- glutamate release in schizophrenia and to inhibit progression of certain neurodegenerative diseases (by reducing intracellular calcium release). It was found that glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid- THC.

2, Cannabinoids are antagonists of the NMDA receptors- so schizophrenia development

Evidence from histological and pharmacological challenge studies indicates that NMDA receptor hypofunction may play an important role in the pathophysiology of schizophrenia. So, marijuana can be a serious problem, because according to the science studies it seems that cannabis use can precipitate schizophrenia in vulnerable individuals (alkoholism, undernutrition…), especially. However, there are other studies about the opposite marijuana effect, so scientists say; „One possibility is that there are good guys and bad guys within cannabis… Maybe the cannabidiol ameliorates some of the effects of the THC and maybe it actually might be good for you if you are psychotic“. I would like to show that there can be a "nutritional theory" (different „body calcium status“ in good and bad guys…) about the cause of schizophrenia based on "calcium deficiency"...

3. The link between the NMDA receptor hyperfunction (neurodegeneration) and hypofunction (schizophrenia)
The goal of my comment is to show that cannabis use can be a proof about this link. See my website http://www.bse-expert.cz , and my opinion- articles in Medical News Today http://www.medicalnewstoday.com/youropinions.php?opinionid=17968 and http://www.medicalnewstoday.com/youropinions.php?opinionid=18538. Because of their central role in neurodegeneration, NMDA receptors have been considered prime therapeutic targets for the development of useful neuroprotective strategies. However, one could imagine that these receptors might be less sensitive to glutamate, and, perhaps, more sensitive to Mg2+ block . So, NMDA receptors may differ in their sensitivity to voltage-dependent Mg2+ block, agonists, and antagonists as a function of their subunit composition.